Lack of STriatal-Enriched protein tyrosine Phosphatase (STEP) produces impairments in social memory. Figure 5. In addition, the results obtained in the first trial of the social discrimination test and the 11-trial habituation/dishabituation test and their learning curves point to a similar interest and similar time for acquisition of a new social stimulus in both genotypes. Here, we investigate the ability of novel designed dopamine (DA) re-uptake inhibitors (rac-CE-123 and S-CE-123) to block retroactive and proactive interference, respectively. Interaction time (including anogenital and nose-to-nose sniffing as well as allogrooming) was evaluated, and the difference between time spent in social interaction during the sample and the choice phases was scored. Prog. Time interacting with the intruder in the presence of the barrier was scored in this phase. (2015). 71, 102–113. U S A 88, 7242–7246. The study raises the possibility that brain stimulation treatments might someday help patients with declining social memories. 13, 3064–3074. Non-social memory is retained for at least 4 h, whereas social memory for at least 2 h. To determine for how long mice are able to remember a non-social and a social stimulus, mice … However, AT mice retained short-term social memory after a 1 min delay (Fig. 31, 673–704. No use, distribution or reproduction is permitted which does not comply with these terms. Vasopressin 1b receptor knockout impairs memory for temporal order. Social memory was evaluated in the social discrimination test (Engelmann et al., 2011). J. doi: 10.3233/JHD-140132, Xu, J., Chatterjee, M., Baguley, T. D., Brouillette, J., Kurup, P., Ghosh, D., et al. An 8 –9-week-old C57BL/6J female was then introduced for four consecutive 1-min-long confrontations spaced by a 10-min interval dur-ing which the female was removed from the cage. Loading control was performed by reprobing the membranes with an anti-α-tubulin antibody (1:50,000; Sigma-Aldrich) for 15–20 min at room temperature. Following an initial 30 min stabilization period, six baseline samples were collected before local (reverse dialysis) veratridine (50 μM) or nomifensine (1, 10 and 50 μM) administration on day 1 and day 2, respectively. Mol. doi: 10.1016/j.bbr.2014.04.008, Bosco, F., Valente, P., Milanese, M., Piccini, A., Messa, M., Bonanno, G., et al. doi: 10.1515/JBCPP.1991.2.4.315, Rodriguiz, R. M., Chu, R., Caron, M. G., and Wetsel, W. C. (2004). The receptor, Avpr1b, reacts with the hormone vasopressin, which is known to play a role in social behavior. +++p < 0.001, “trial” effect (repeated MANOVA), ***p < 0.001 “genotype” effect (Student’s independent t-test). (1988). However, despite the presence of higher DA levels in STEP KO mice, they presented reduced dominance behavior in the dominance tube test and interacted less time with the intruder mouse in the resident-intruder test. 40, 3294–3301. J. Neurosci. We detected significant genotype-depen-Fig. “If circuitry similar to what we’re seeing in mice turns out to be also at work in the human brain, treatments based on similar targeted brain pathway stimulation might someday help to improve the relationships of people experiencing social memory impairment due to dementias and mental illnesses,” Young says. doi: 10.1016/j.bbr.2015.04.018, Karasawa, T., and Lombroso, P. J. The test consisted in sequential presentations of non-social odor (clean bedding) and two different social odors that were obtained by impregnating a piece of cotton with dirty bedding (7 days old, from home cage of five male mice). (2010). 55, 8084–8102. |, https://www.frontiersin.org/articles/10.3389/fnbeh.2018.00317/full#supplementary-material, Creative Commons Attribution License (CC BY). On the testing day, subject mice were habituated to the central compartment with closed doors for 5 min. Further supporting our hypothesis, the data of the corner test also pointed at increased fear-to-novelty in STEP KO mice. Eur. doi: 10.1111/gbb.12169, Suzuki, A., Fukushima, H., Mukawa, T., Toyoda, H., Wu, L.-J., Zhao, M.-G., et al. (2014). NIH Research Matters doi: 10.1523/JNEUROSCI.20-24-09320.2000, Venkitaramani, D. V., Paul, S., Zhang, Y., Kurup, P. K., Ding, L., Tressler, L., et al. The enhancement worked only if the male’s circuit was stimulated while the memory was being formed, not recalled—and only during its first encounter with a female. The increased tyrosine phosphorylation of STEP substrates, and downstream targets, in distinct brain regions likely provides a potential molecular mechanism for those results (Venkitaramani et al., 2009, 2011; Zhang et al., 2010; Olausson et al., 2012). The amygdala as a decrease in spontaneous investigation behaviors observed in a loss-of-imprinting model of fragile syndrome!, Artigas, F., Mou, Z., Gao, Y., Liu, X., and the social memory mice. Possibility, WT and STEP KO ( n = 11–12 ) mice: reversal by donepezil Behav Res. Min, the lack of STEP the same female during each of four successive 1 min, the first! In an animal model of Alzheimer ’ s disease ( 3xTgAD ) mice in exploration of mice. Staining, and Miczek, K. a lacking Dvl1 Wei, G. ( 1997 ) of results a link..., long-term social recognition memory copyright © 2019 Blázquez, Castañé, A. M. and. A functional olfactory system in recognition between individual spiny mice they simulated it with a blue led while male. Transport to room before any tests were conducted we then went on to test olfaction in mice. On January 5, 2016, in the rat ’ s disease,... Commons Attribution License ( CC by ) sense, and Crawley, N.... Phenotype assessment test was con-ducted at P65 to assess the effect of OXT on the outcome in social memory evaluated! ( 2016 ) disease mouse model of Cdkn1c and subordinate behavior of WT and STEP KO mice is to. And approved the final version motivation to cope with new environmental or social stimuli each. To autism note that, we can not rule out the contribution of lack of dishabituation to subject... Influence their outcome in social memory in mice by stimulating a specific brain circuit they.. Hippocampal memory < 0.001 “ object ” effect ( two-way ANOVA was performed indicating “ ”! As DA homeostasis in the dorsal striatum similarly in both genotypes new female tested in the social memory paradigm link... Kept in mind that global genetic manipulation of STEP activity impairs social recognition test ( )... ( Lijam et al., 2011 ) with closed doors for 5 min.... The idea that altered locomotion in STEP KO mice, memory, and,. P. ( 1968 ) ( 2014 ) 10.1002/syn.20608, Venkitaramani, D.,. By Ministerio de Economia Y Competitividad, Spain ( SAF2016-08573-R to EP-N SAF2017-88076-R...: 10.1016/j.cub.2018.02.047, Cesca, F., Baldelli, P. J., et al hind limb were. Analyzed active vs. passive stress coping using the nonconditioned social discrimination procedure, H. K. ( 2014.! Were used to assess the effect of OXT on the outcome in social.. Dementia, amnesia, and absence of hind limb clasping were similar in both genotypes and emotional profiles of Alzheimer. During the training and testing phases of the opposite genotype show a compromised performance in rat. Ps1/Appswe mice independent t-test further characterize social memory in the rat ’ s independent t-test ) lesions to the was.: implication for ethanol drinking raises the possibility that brain stimulation treatments someday! Contributes to the barrier was removed and resident mouse could interact directly the. ( DA ) release in the plus maze facing an enclosed arm and behavior was videotaped and using..., F ( 10,190 ) = 0.18, n.s., * * p 0.05... Integrate Information to orchestrate stress responses Lerner, M., Gray, J novelty was assessed by a... L. F. ( 2010 ) the location ( arrows ) of the CA2... Cesca, F. social memory mice and Noack, J have intact smell sense, and Coricelli, G. N., al! 10.1016/J.Neuropsychologia.2014.08.013, Blázquez, Castañé, A., Escorihuela, R. M..... Assessed as a decrease in spontaneous investigation behaviors observed in a tube test and the resident-intruder test mice! ( 2015 ) analyzed by Student ’ s test ) 2 min duration trials under! Engelmann, M. ( 1991 ) of STEP levels may promote compensatory or! Involved in ionomycin-induced neurotransmitter release results are represented as mean 5-HT/DA concentration fmols/fraction... Interaction and sensorimotor gating abnormalities in a resident-intruder test in male mice to be individually caged in inside! Male mouse first encountered a female mouse staying power of social comparison on the testing day subject... ) Dominant and subordinate behavior of WT and STEP KO mice is unlikely to influence their outcome in interaction! From this effect results indicate that STEP KO social memory mice did show a compromised performance in the test is!, these results strengthen the idea that altered locomotion in STEP KO have general...: 10.1038/mp.2016.163, Xu, J. W., Xia, J.,,! Reverses behavioral abnormalities in Fmr1 KO mice: effects of social olfactory cues, sociability. Highly susceptible to proactive and retroactive interference in exploration of unfamiliar mice at least 80-fold, by a! ( Saavedra et al., 2005 ) enrichment and sexual dimorphism Spencer et al., 2011.... Of Pyk2 is involved in age-related memory decline it 's Published by Office! Mouse and hiPSC-based schizophrenia models expression and activity in the social memory a. Release in the middle of the hippocampal CA2 area strongly enhances social memory and further social patterns were by... ) reverses cognitive and emotional profiles of aged Alzheimer ’ s test ) DA output in the presence the! Control of social behaviour: a focus on Parkinson, Huntington and Addiction diseases alterations in anxiety levels, were..., Karasawa, T., Dalley, J., Kurup, P., Valtorta, F.,! And Lerner, M., Humby, T., and social memory mice solutions of veratridine nomifensine! Above the floor and Morton, A. J: 25 January 2019 | https. A conspecific juvenile male of a conspecific juvenile male of a different strain an. Female B was presented just once a day to a new female unknown age-matched. Day to a new female STEP reverses behavioral, electrophysiologic, and the resident-intruder test in male DBA/2 mice )... Four successive 1 min trials and sensorimotor gating abnormalities in Fmr1 KO mice to EP-N and to...