Methocarbamol used for relaxing tensed muscles can be combined with acetaminophen, which is an OTC pain reliever. More patients given tizanidine/ibuprofen suffered drowsiness and other central nervous system effects (P = 0.025). I am happy that you got the info you needed regarding taking Tizanidine and Percocet together. In most cases you may take tizanidine up to 3 times in one day if needed. Methocarbamol-acetaminophen may be taken in the form of combination … These medications may interact and cause very harmful effects. You may take tizanidine with or without food, but take it the same way each time. This review analyzes which people have Oropharyngeal pain with Tizanidine hydrochloride and Tylenol. A positive rating lets me and others know that you would trust me with your pharmacy inquiries and would recommend me to your family and friends. Oropharyngeal pain is found among people who take Tizanidine hydrochloride and Tylenol, especially for people who are female, 50-59 old also take medication Actonel, and have High blood pressure. We have answered the question “Can I take Tylenol with Prednisone?” as we found no major reported interactions, however, it doesn’t mean they are non-existent. Despite that Tylenol is OTC medication, it is also cheaper in comparison to Robaxin cost and can be used to save some money during the treatment course. Tizanidine and Tylenol do not affect one another. In patients with severe acute low-back pain, however, some sedation and bed rest is advantageous. 1 doctor agrees. Allow 6 to 8 hours to pass between doses. Answered on Apr 9, 2019. 0 thank. “So, this is the potential mechanism for a reduced immune response to vaccination if you take these medications.” As COVID-19 vaccinations are rolled out across the country, you might be wondering if it is OK to take pain relievers before or after receiving a shot. Talk to your healthcare provider before starting treatment to discuss any interactions that may apply to you. Safe: They are safe to take together. Get help now: Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. There is an interaction between Zanaflex (tizanidine) and Soma (carisoprodol) in that they can have additive side effects, like sedation and cognitive impairment, when used together. 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